Neonatal Intensive Care

The Neonatal Intensive Care Unit (NICU) research group is a multi-disciplinary group that participates in many types of research that affect the care of newborn infants, from the extremely preterm to the critically ill term infant.  The group consists of neonatologists, NICU fellows, nursing researchers, research collaborators from other departments at CHEO and a dedicated NICU research coordinator. The research done by our group includes database research, randomized controlled trials, laboratory (pre-clinical) research, quality-improvement and neonatal follow-up research. The overall aim of our research group is to improve the care provided to preterm and critically ill newborn infants.

Significant areas of research include:

  • leading edge treatments for chronic lung disease of prematurity
  • neonatal pain management
  • detection and treatment of severe intestinal disease in premature infants
  • shared decision making at the limit of viability
  • mock codes teaching to trainees
  • methods for teaching trainees the ethics of working with this vulnerable population
  • detection of seizure activity in sick neonates
  • methods to improve team communication during medical emergency care
  • improvements in newborn screening for treatable disorders
  • outcome predictions for sick patients in the NICU
  • treatment of respiratory distress in preterm infants
  • improvement of infant survival in developing countries
  • Point of care ultrasound use in the NICU
  • Management of patent ductus arteriosus and use of Targeted Neonatal Echo in the NICU

 

Research Projects

  1. Evaluating parental perceptions of written handbooks provided during shared decision making with parents anticipating extremely preterm birth

    27/07/2020

    Overall, parents positively evaluated the handbooks, supporting their utility for parents anticipating extremely preterm birth. Concrete suggestions for improvement were made; the handbooks will be modified accordingly. Parents at other perinatal centers may benefit from receiving such handbooks.

  2. Whole-body vibration in neonatal transport: a review of current knowledge and future research challenges

    01/07/2020

    This review intends to highlight what is known about vibration as a physical stressor in neonates and areas for further research; with the goal to making recommendations for minimizing these stressors during transport.

  3. Characterization of the innate immune response in a novel murine model mimicking bronchopulmonary dysplasia

    01/05/2020

    This is the first report of in-depth characterization of the lung injury and recovery describing the evolution of the innate immune response in a standardized mouse model for experimental BPD with postnatal LPS and hyperoxia exposure.

  4. Paediatric ethical issues during the COVID‐19 pandemic are not just about ventilator triage

    01/05/2020

    the COVID‐19 pandemic is creating many ethical challenges. One of the most difficult is for ethicists to focus on the issues that are likely to have the greatest impact. Ventilator allocation in a crisis situation is a deeply tragic choice that requires careful balancing of a number of values

  5. A novel method for quantitation of acylglycines in human dried blood spots by UPLC-tandem mass spectrometry

    01/04/2020

    This method shows potential application as a second tier screen in order to reduce the false positive rate for a number of IEM targeted by newborn screening.

  6. Exploring Acceptance and Commitment Therapy for parents of preterm infants

    01/02/2020

    One promising intervention that has not been explored in the NICU is Acceptance and Commitment Therapy (ACT), a behavioural therapy that has had positive mental health-related outcomes in similar parental populations.

  7. Racial differences in contribution of prepregnancy obesity and excessive gestational weight gain to large-for-gestational-age neonates

    01/02/2020

    Excessive gestational weight gain contributed more to LGA neonates than prepregnancy obesity in Whites and Asians, while there was no difference between excessive gestational weight gain and prepregnancy obesity in their contributions to the LGA neonates in Blacks. The differences are mostly driven by the differential prevalence of the two risk factors across racial groups.

  8. The transplacental passage of commonly used intrapartum antibiotics and its impact on the newborn management: A narrative review

    09/08/2019

    Maternally-administered ampicillin, penicillin, and cefazolin rapidly achieve therapeutic levels in the fetal circulation.

  9. Racial/ethnic variations in gestational weight gain: a population-based study in Ontario

    09/08/2019

    Inadequate and excessive gestational weight gain (GWG) have both been linked with a number of adverse maternal and neonatal outcomes, which in turn also vary by race/ethnicity (Headen et al. 2012).

  10. Do transport factors increase the risk of severe brain injury in outborn infants less than 33 weeks gestational age?

    01/08/2019

    Risk factors for SBI were related to the condition at birth and immediate postnatal management and not related to transport factors. These results highlight the importance of maternal transfer to perinatal centers to allow optimization of perinatal management.

  11. Association Between Self-reported Prenatal Cannabis Use and Maternal, Perinatal, and Neonatal Outcomes

    18/06/2019

    Among pregnant women in Ontario, Canada, reported cannabis use was significantly associated with an increased risk of preterm birth.

  12. Infrared Imaging Tools for Necrotizing Enterocolitis (NEC) Diagnosis Guided by RGB-D Sensing

    01/05/2019

    In this paper, we present a novel automated image acquisition and processing system that integrates infrared and RGB-D sensors for NEC detection.

  13. Target oxygen saturation and development of pulmonary hypertension and increased pulmonary vascular resistance in preterm infants

    01/01/2019

    Higher targeted oxygen saturation was associated with reduced risk of PH or elevated PVR in extremely preterm infants compared to lower oxygen saturation target.

  14. Hypothermia for Newborns With Hypoxic-Ischemic Encephalopathy

    12/06/2018

    Because some studies included infants born at 35 weeks GA, hypothermia should be considered if they meet other criteria.

  15. Counselling and Management for Anticipated Extremely Preterm Birth

    01/09/2017

    Counselling couples facing the birth of an extremely preterm infant is a complex and delicate task, entailing both challenges and opportunities.

  16. Resolution of refractory hypotension and anuria in a premature newborn with loss-of-function of ACE

    01/07/2015

    Vasopressin was used to successfully treat refractory hypotension and anuria in the neonate born at 27 weeks of gestation.

  17. Occult Tethered Cord Syndrome: A Review

    03/09/2013

    As occult tethered cord syndrome becomes increasingly recognized, it is important to be aware of the potential benefits of operative intervention for appropriately selected patients.

  18. New Intrauterine Growth Curves Based on United States Data

    01/01/2010

    Final sample included 257 855 singleton infants (57.2% male) who survived to discharge.

Researchers

  1. Erika Bariciak

    Investigator, CHEO Research Institute

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  2. Nadya Ben Fadel

    Investigator, CHEO Research Institute

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  3. Kym M Boycott

    Senior Scientist, CHEO Research Institute

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  4. Daniel Corsi

    Scientist, CHEO Research Institute

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  5. David A. Dyment

    Investigator, CHEO Research Institute

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  6. Deshayne Fell

    Scientist, CHEO Research Institute

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  7. Yanfang Guo

    Investigator, CHEO Research Institute

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  8. Sherri Katz

    Senior Scientist, CHEO Research Institute

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  9. Margaret Lawson

    Senior Scientist, CHEO Research Institute

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  10. Brigitte Lemyre

    Investigator, CHEO Research Institute

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  11. Nathalie Lepage

    Investigator, CHEO Research Institute

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  12. Nathalie Major

    Investigator, CHEO Research Institute

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  13. Kusum Menon

    Senior Scientist, CHEO Research Institute

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  14. Gregory Moore

    Investigator, CHEO Research Institute

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  15. Stephanie Redpath

    Investigator, CHEO Research Institute

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  16. Nicole Rouvinez Bouali

    Investigator, CHEO Research Institute

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  17. Bernard Thébaud

    Senior Scientist, CHEO Research Institute

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  18. Albert Tu

    Investigator, CHEO Research Institute

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Family Leaders

  1. Andy Statia

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  2. Anne Maloney

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  3. Bleadon Anderson

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  4. Ellen Song

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  5. Erin Fobert

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  6. Heather MacPhail

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  7. Jessica Hay

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  8. Julie Keon

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  9. Kieran Peacock

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  10. Laurie Woodward

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  11. Leanne van der Zweep

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  12. Linda Lefebvre

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  13. Michelle Vautour-Shales

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  14. Samantha Bellefeuille

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  15. Tysen Lefebvre

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