Do transport factors increase the risk of severe brain injury in outborn infants less than 33 weeks gestational age?

We evaluated transport factors and postnatal practices to identify modifiable risk factors for SBI.

Study design
Retrospective review of Canadian Neonatal Transport Network data linked to Canadian Neonatal Network data for outborns <33 weeks gestational age (GA), during January 2014 to December 2015. SBI was defined as grade 3 or 4 intraventricular hemorrhage or parenchymal echogenicity, including hemorrhagic and/or ischemic lesions.

Among 781 infants, 115 (14.7%) had SBI with range 5.6–40% among transport teams. In multivariable analysis, SBI was associated with GA [0.77 (0.71, 0.85)] per week, receipt of chest compressions and/or epinephrine at delivery [1.81 (1.08, 3.05)] and receipt of fluid boluses [1.61 (1.00, 2.58)].

Risk factors for SBI were related to the condition at birth and immediate postnatal management and not related to transport factors. These results highlight the importance of maternal transfer to perinatal centers to allow optimization of perinatal management.

Lead Researchers

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  1. Stephanie Redpath

    Investigator, CHEO Research Institute

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  2. Gregory Moore

    Investigator, CHEO Research Institute

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