Discoveries

Averageing over 500 scientific publications a year, the CHEO Research Institute knows that patients, families, and the comunity need to be able to access our findings in order to educate themselves on the breakthroughs in pediatrac patient care Research.

  1. When Should Bisphosphonates Be Used in Children with Chronic Illness Osteoporosis?

    19/06/2021

    The decision to treat a child with a bisphosphonate hinges on distinguishing bone fragility from typical childhood fractures, and determining the potential for medication-unassisted recovery following an osteoporotic fragility fracture. While improvements in BMD are a well-known sign of recovery, restitution of bone structure is also a key indicator of recuperation, one that is unique to childhood, and that plays a pivotal role in the decision to intervene or not.

  2. Vitamin D supplementation for children with cancer: a systematic review and consensus recommendations

    08/06/2021

    Further research is needed; until then, we recommend dietary vitamin D/calcium intake in keeping with standard national guidelines, and periodic 25OHD monitoring to detect levels <20 ng/ml. Vitamin D/calcium supplementation is recommended in children with low levels, to maintain levels ≥20 ng/ml year-long.

  3. Aerosol SARS-CoV-2 in hospitals and long-term care homes during the COVID-19 pandemic

    04/06/2021

    Although a subset of aerosol samples exhibited detectable SARS-CoV-2 RNA at low titres, the presence of viable SARS-CoV-2 virus in aerosols appears to be infrequent at >2m distance.

  4. Skin Testing for Penicillin Allergy: a Review of the Literature

    18/03/2021

    This review provides support for risk stratification assessment of reported penicillin allergy to optimize antibiotic use and prevent emergence of antimicrobial resistance.

  5. Evaluating the utility of synthetic COVID-19 case data

    01/03/2021

    A privacy risk assessment on the synthetic data showed that the attribute and membership disclosure risks were low.

  6. SARS-CoV2 Infection in Children with Liver Transplant and Native Liver Disease: An International Observational Registry Study

    16/02/2021

    Future controlled studies are needed to evaluate effective treatments and further stratify LD and LT patients with SARS-CoV2 infection.

  7. Psychiatric disorders in emerging adults with diabetes transitioning to adult care: a retrospective cohort study

    12/02/2021

    Prolonged gaps in care during transfer to adult care are common and may be associated with increased psychiatric disorder risk. Developmental factors associated with adolescence and emerging adulthood may further amplify this risk.

  8. Identification of pannexin 1-regulated genes, interactome, and pathways in rhabdomyosarcoma and its tumor inhibitory interaction with AHNAK.

    09/02/2021

    Using this unbiased genome-wide approach, our transcriptomic analysis identified the genes that are regulated in PANX1-expressing RMS cells together with the key cellular processes in which they may be involved.