Nathalie Major

Investigator, CHEO Research Institute

Dr. Major is the Medical Director for the Complex Medical Care Program at CHEO.  She is involved in a variety of research projects specific to the population of children with
medical complexity (CMC) and on integrated care model. While supporting the implementation of a province wide complex care program called Complex Care for Kids Ontario (CCKO), Dr Major is the site lead for a provincial clinical trial  A Province-Wide Integrated Care Intervention for Children with Medical Complexity (CMC) using a Patient-Engaged Evaluation Framework. CCKO brings researchers, families and healthcare providers together to develop, implement and evaluate a population-level roll-out of care for CMC in Ontario, through a randomised controlled trial (RCT) design. The intervention includes dedicated key workers and the utilisation of coordinated shared care plans.

She is also the Co-Principle Investigator for a multicenter mixed methods pragmatic randomized controlled trial on integrated model design for complex care called Coached-Coordinated-Enhanced Neonatal Transition (CCENT). The clinical trial involves a key worker who will support families of high risk neonate by 1) helping with  care coordination as well as 2) parental coaching using a mindfulness approach and 3) providing proactive educational support while in transition to home and until the child is 1 year of age. The goal is to improve the psychosocial support and medical care coordination beyond the neonatal intensive care unit. We hope to change the experience of stress, and health of the families.

Research Projects

  1. Exploring Acceptance and Commitment Therapy for parents of preterm infants


    One promising intervention that has not been explored in the NICU is Acceptance and Commitment Therapy (ACT), a behavioural therapy that has had positive mental health-related outcomes in similar parental populations.

  2. Complex care for kids Ontario: protocol for a mixed-methods randomised controlled trial of a population-level care coordination initiative for children with medical complexity

    Our primary objective is to evaluate the CCKO intervention using a randomised waitlist control design. The waitlist approach involves rolling out an intervention over time, whereby all participants are randomised into two groups (A and B) to receive the intervention at different time points determined at random.