Pain

CHEO is a world leader in pediatric pain research. Research conducted by CHEO and CHEO RI staff include development and testing of pain assessment tools, pain prevalence studies, systematic reviews of pain interventions in infants and children, randomized controlled trials of pain management interventions, and knowledge translation studies concerning improving pain management in hospitalized infants and children.

Research Projects

Evaluating the French version of an online training course for a pediatric pain assessment scale
24/01/2022

Discussion: An improvement of the quality of videos linked to mild pain, and the quantity of videos for all levels of pain, is required for this study to be replicated among a larger sample.
Modeling adult COX-2 cerebrospinal fluid pharmacokinetics to inform pediatric investigation
01/11/2021

Transfer of unbound COX-2 inhibitors from plasma to CSF compartment can be described with a delayed effect model using an equilibration rate constant to collapse observed hysteresis. An additional transfer factor was required to account for passage across the blood-brain barrier. Use of a target concentration strategy for dose and consequent plasma (total and unbound) and CSF concentration prediction could be used to inform pediatric clinical studies.
Medications to manage infant pain, distress and end-of-life symptoms in the immediate postpartum period
18/08/2021
Medications to manage end-of-life symptoms in the immediate postpartum period
18/08/2021

There is a need for standardization of the medical management of infants born with life-limiting conditions whose parents choose to pursue palliative care.
Development and pilot evaluation of an educational tool for the FLACC pain scale
01/12/2020

This study aimed to develop an online educational tool and evaluate its effect on nurse knowledge, user confidence, and scoring accuracy.
Cannabis use for therapeutic purposes by children and youth at a tertiary teaching hospital in Canada: A retrospective chart review
02/03/2020

Medically supervised cannabis use occurred most often in patients with intractable or refractory seizures. According to these data, seizure response is variable, and initial decreases may be transient for pediatric patients using cannabis. To ensure greater consistency and rigour in the conduct of prospective research and thus to generate better-quality research on the therapeutic effects of medical cannabis, development of a standardized care record is needed.
Predictors of postoperative respiratory complications in children undergoing adenotonsillectomy
15/01/2020

Prediction modeling concurrently evaluating comorbidities and polysomnography metrics identified cardiac disease, airway anomaly, and young age as independent predictors of PRAEs. These findings suggest that medical comorbidity and age are more important factors in predicting PRAEs than PSG metrics in a medically complex population.
The Accuracy of Prevalent Vertebral Fracture Detection in Children Using Targeted Case‐Finding Approaches
01/11/2019

Back pain was assessed by patient report, LS BMD was measured by dual‐energy X‐ray absorptiometry, and PVF were quantified on spine radiographs using the modified Genant semiquantitative method. Forty‐four patients (11.0%) had PVF.
No association between metoclopramide treatment in ED and reduced risk of post-concussion headache
04/12/2018

Further research is necessary to determine which pharmacotherapies may be effective for acute and persistent post-concussive headache.