Pain

CHEO is a world leader in pediatric pain research. Research conducted by CHEO and CHEO RI staff include development and testing of pain assessment tools, pain prevalence studies, systematic reviews of pain interventions in infants and children, randomized controlled trials of pain management interventions, and knowledge translation studies concerning improving pain management in hospitalized infants and children.

Research Projects

  1. Virtual psychoeducation for improvement of pain catastrophizing in pediatric presurgical patients and caregivers: A proof-of-concept study

    03/10/2024

    Youth (n = 43) and caregivers (n = 41) attended a virtual, group-based single-session intervention (SSI). Single-session intervention content addressed pain neuroscience, PC, and adaptive coping strategies for managing pain and PC drawn from cognitive-behavioural, acceptance and commitment, and dialectical behaviour therapy approaches. Participants completed questionnaires assessing PC at preintervention, postintervention, and two weeks postsurgery. Youth mood and anxiety were assessed at preintervention.

  2. Evaluating the French version of an online training course for a pediatric pain assessment scale

    24/01/2022

    Discussion: An improvement of the quality of videos linked to mild pain, and the quantity of videos for all levels of pain, is required for this study to be replicated among a larger sample.

  3. Modeling adult COX-2 cerebrospinal fluid pharmacokinetics to inform pediatric investigation

    01/11/2021

    Transfer of unbound COX-2 inhibitors from plasma to CSF compartment can be described with a delayed effect model using an equilibration rate constant to collapse observed hysteresis. An additional transfer factor was required to account for passage across the blood-brain barrier. Use of a target concentration strategy for dose and consequent plasma (total and unbound) and CSF concentration prediction could be used to inform pediatric clinical studies.

  4. Medications to manage end-of-life symptoms in the immediate postpartum period

    18/08/2021

    There is a need for standardization of the medical management of infants born with life-limiting conditions whose parents choose to pursue palliative care.

  5. Medications to manage infant pain, distress and end-of-life symptoms in the immediate postpartum period

    18/08/2021

  6. Development and pilot evaluation of an educational tool for the FLACC pain scale

    01/12/2020

    This study aimed to develop an online educational tool and evaluate its effect on nurse knowledge, user confidence, and scoring accuracy.

  7. Cannabis use for therapeutic purposes by children and youth at a tertiary teaching hospital in Canada: A retrospective chart review

    02/03/2020

    Medically supervised cannabis use occurred most often in patients with intractable or refractory seizures. According to these data, seizure response is variable, and initial decreases may be transient for pediatric patients using cannabis. To ensure greater consistency and rigour in the conduct of prospective research and thus to generate better-quality research on the therapeutic effects of medical cannabis, development of a standardized care record is needed.

  8. Predictors of postoperative respiratory complications in children undergoing adenotonsillectomy

    15/01/2020

    Prediction modeling concurrently evaluating comorbidities and polysomnography metrics identified cardiac disease, airway anomaly, and young age as independent predictors of PRAEs. These findings suggest that medical comorbidity and age are more important factors in predicting PRAEs than PSG metrics in a medically complex population.

  9. The Accuracy of Prevalent Vertebral Fracture Detection in Children Using Targeted Case‐Finding Approaches

    01/11/2019

    Back pain was assessed by patient report, LS BMD was measured by dual‐energy X‐ray absorptiometry, and PVF were quantified on spine radiographs using the modified Genant semiquantitative method. Forty‐four patients (11.0%) had PVF.

  10. No association between metoclopramide treatment in ED and reduced risk of post-concussion headache

    04/12/2018

    Further research is necessary to determine which pharmacotherapies may be effective for acute and persistent post-concussive headache.

Researchers

  1. Nick Barrowman

    Associate Scientist, CHEO Research Institute

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  2. Maala Bhatt

    Scientist, CHEO Research Institute

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  3. Natalie Bresee

    Investigator, CHEO Research Institute

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  4. Matthew Bromwich

    Investigator, CHEO Research Institute

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  5. Juliana Choueiry

    Investigator, CHEO Research Institute

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  6. Dawn Davies

    Investigator, CHEO Research Institute

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  7. Emanuela Ferretti

    Investigator, CHEO Research Institute

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  8. Sherri Katz

    Senior Scientist, CHEO Research Institute

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  9. Andrée-Anne Ledoux

    Scientist CHEO Research Institute

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  10. Claudia Malic

    Investigator, CHEO Research Institute

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  11. Danijela Maras

    Investigator, CHEO Research Institute

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  12. Kimmo Murto

    Investigator, CHEO Research Institute

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  13. Christina Vadeboncoeur

    Investigator, CHEO Research Institute

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  14. Private: Régis Vaillancourt

    Senior Scientist, CHEO Research Institute

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  15. Stephanie Veldhuijzen van Zanten

    Investigator, CHEO Research Institute

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  16. Leanne Ward

    Senior Scientist, CHEO Research Institute

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  17. Roger Zemek

    Senior Scientist, CHEO Research Institute

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Family Leaders

  1. Adam Fobert

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  2. Adeseun Ilori

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  3. Angie Hamson

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  4. Assil Issa

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  5. Bina Sharma

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  6. Carly Haydt

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  7. Cassandra Schopf

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  8. Ellen Song

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  9. Jessica Hay

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  10. Kieran Peacock

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  11. Laurie Woodward

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  12. Mairead Green

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  13. Mariann Michael

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  14. Natalie del Signore

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  15. Natasha Baechler

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  16. Samantha Bellefeuille

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  17. Trinity Lowthian

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