Nick Barrowman

Associate Scientist, CHEO Research Institute

Nick Barrowman is a PhD biostatistician with over 20 years of experience in the design and analysis of clinical studies. He is a Senior Statistician at the Clinical Research Unit of the CHEO RI and Associate Professor in the Department of Pediatrics at the University of Ottawa. He has published over 200 peer-reviewed papers in diverse fields and has also served as President of the Statistical Society of Ottawa and Statistical Consultant for the Canadian Medical Association Journal.

Area of Research: Biostatistics

Research Projects

  1. Circadian cortisol secretion in adolescent girls with conduct disorder

    07/11/2022

    This study advanced our knowledge about girls with severe antisocial behavior, discovering that lower circadian cortisol secretion is present in girls with CD, but largely due to decreased volume of cortisol secretion between awakening and 30-minutes post-awakening time. Comorbid internalizing disorders were not associated with differences in circadian secretion of cortisol, compared to girls with only CD.

  2. Is early activity resumption after paediatric concussion safe and does it reduce symptom burden at 2 weeks post injury? The Pediatric Concussion Assessment of Rest and Exertion (PedCARE) multicentre randomised clinical trial.

    15/03/2022

    PA is a promising concussion treatment. Post-concussion symptoms at 2weeks did not differ significantly between children/ youth with acute concussion randomised to initiate PA at 72 hours post injury versus those instructed to rest-until-asymptomatic.

  3. Housing conditions and respiratory morbidity in Indigenous children in remote communities in Northwestern Ontario, Canada

    24/01/2022

    Many houses in these FN communities had substantial IEQ problems. Presence of endotoxin was associated with wheezing with colds and tended to be associated with LRTI in young children. Surface area of visible mould tended to be associated with URTI visits. Urgent collective action is needed to respond to historically damaging impacts of colonization, including systemic indifference.

  4. Intermittent vs Continuous Pulse Oximetry in Hospitalized Infants With Stabilized Bronchiolitis

    01/03/2021

    In this randomized clinical trial, among infants hospitalized with stabilized bronchiolitis with and without hypoxia and managed using an oxygen saturation target of 90% or higher, clinical outcomes, including length of hospital stay and safety, were similar with intermittent vs continuous pulse oximetry. Nursing satisfaction was greater with intermittent monitoring. Given that other important clinical practice considerations favor less intense monitoring, these findings support the standard use of intermittent pulse oximetry in stable infants hospitalized with bronchiolitis.

  5. Predictors of postoperative respiratory complications in children undergoing adenotonsillectomy

    15/01/2020

    Prediction modeling concurrently evaluating comorbidities and polysomnography metrics identified cardiac disease, airway anomaly, and young age as independent predictors of PRAEs. These findings suggest that medical comorbidity and age are more important factors in predicting PRAEs than PSG metrics in a medically complex population.