Andrée-Anne Ledoux

Scientist CHEO Research Institute

Dr. Ledoux is a Scientist at the CHEO Research Institute and Assistant Professor for the Cellular Molecular Medicine Department at University of Ottawa. Dr. Ledoux has a PhD in Experimental Psychology and Behavioural Neuroscience.

Dr. Ledoux and her team is interested in developing and testing management protocols that target neuronal repair in the hopes of reducing the risk of persistent post-concussive symptoms, reducing the recovery period, and promoting resiliency and neural protection in pediatric concussion. She is interested in identifying recovery neural correlates that can be used as recovery biomarkers in concussion and investigating how behavioural treatments can modify these biomarkers. She is currently investigating the acute and subacute clinical, neuropsychological and neurophysiological recovery processes of two different behavioural management protocols: early return to physical activity and mindfulness-based intervention with MRI. Given the extensive brain maturation and significant functional development that occurs throughout childhood in addition to the sex differences that exist throughout development, she also explores age and sex-based differences in all of her concussion-related studies. Together with a multidisciplinary approach, cutting edge techniques and national/international collaborations she hopes to reduce the impact of concussion in children and adolescents and their family.

Research Projects

  1. Symptom Burden, School Function, and Physical Activity One-Year Following Pediatric Concussion

    25/08/2020

    Most youth are symptom-free and fully recovered one year following concussion. Some children with repeat concussion have worse outcomes and have delays in returning to normal school routines and sport.

  2. Early versus delayed emergency department presentation following mild Traumatic Brain Injury and the presence of symptom at 1, 4 and 12 weeks in children

    05/03/2020

    We evaluated the association between timing of presentation and postconcussive symptoms (PCS) at 1, 4 and 12 weeks after injury.

  3. Natural Progression of Symptom Change and Recovery From Concussion in a Pediatric Population

    04/01/2019

    It may be that between-sex differences in adolescents should be taken into consideration for recovery management; the derived recovery curves may be useful for evidence-based anticipatory guidance.

  4. Multicentre, randomised clinical trial of paediatric concussion assessment of rest and exertion (PedCARE)

    01/07/2017

    This trial will determine if early resumption of non-contact physical activity following concussion reduces the burden of concussion and will provide healthcare professionals with the evidence by which to recommend the best timing of reintroducing physical activities.