Respiratory

Overall, chronic lung disease accounts for more than six per cent of annual health-care costs in Canada, and COPD is the leading cause of hospitalization. A large number of Canadians with COPD and asthma, and other lung diseases such as cystic fibrosis and neonatal lung disease need to be further researched

Research Projects

  1. Decontaminating N95 and SN95 masks with ultraviolet germicidal irradiation does not impair mask efficacy and safety

    13/08/2020

    Our findings suggest that further work in this area (or translation to a clinical setting) should use a cumulative UV-C dose of 40,000 J/m2 or greater, and confirm appropriate mask fit following decontamination.

  2. Decontamination Interventions for the Reuse of Surgical Mask Personal Protective Equipment: A Systematic Review

    10/08/2020

    There is limited evidence on the safety or efficacy of surgical mask decontamination. Given the heterogeneous methods used in studies to date, we are unable to draw conclusions on the most efficacious and safe intervention for decontaminating surgical masks.

  3. Care recommendations for the respiratory complications of esophageal atresia-tracheoesophageal fistula

    27/07/2020

    Tracheoesophageal fistula (TEF) with esophageal atresia (EA) is a common congenital anomaly that is associated with significant respiratory morbidity throughout life. The objective of this document is to provide a framework for the diagnosis and management of the respiratory complications that are associated with the condition.

  4. Characterization of the innate immune response in a novel murine model mimicking bronchopulmonary dysplasia

    01/05/2020

    This is the first report of in-depth characterization of the lung injury and recovery describing the evolution of the innate immune response in a standardized mouse model for experimental BPD with postnatal LPS and hyperoxia exposure.

  5. Tuberculosis among First Nations, Inuit and Métis children and youth in Canada: Beyond medical management

    14/01/2020

    Historical TB control practices in Canada have contributed to stigma and discrimination toward those with the disease, as well as fear and mistrust of the health system.

  6. Understanding parent perceptions of healthy physical activity for their child with a chronic medical condition: A cross-sectional study

    01/06/2019

    Over one-third of parents reported having questions about physical activity for their child with a chronic medical condition, suggesting substantial uncertainty even among children reported as active. Presence of parent uncertainty is associated with parent reports of the child being unwell or a history of cardiac arrhythmia

  7. Oral aspiration, type 1 laryngeal cleft, and respiratory tract infections in canadian inuit children

    01/06/2019

    We conclude that swallowing dysfunction is not only prevalent amongst Canadian Inuit but clinically significant. This is the first study to demonstrate an association between swallowing dysfunction and respiratory morbidity in this population.

  8. Sodium nitrite augments lung S-nitrosylation and reverses chronic hypoxic pulmonary hypertension in juvenile rats

    10/10/2018

    Chronic PHT heralds a greatly increased risk of death and severe morbidity, and no therapies yet exist that are proven to modify the disease course.

  9. Insulin Resistance and Hypertension in Obese Youth With Sleep-Disordered Breathing Treated With Positive Airway Pressure: A Prospective Multicenter Study

    01/09/2017

    In youth with obesity and SDB, metabolic dysfunction and hypertension were highly prevalent. Larger, longer-term studies are needed to determine whether PAP improves cardiometabolic outcomes in obese youth.

  10. Long-Term Effects of Lung Volume Recruitment on Maximal Inspiratory Capacity and Vital Capacity in Duchenne Muscular Dystrophy

    08/07/2015

    With lung volume recruitment therapy, MIC–VC differences were stable over time, indicating that respiratory system compliance remains stable, despite a loss in VC, in individuals with Duchenne muscular dystrophy.

  11. Bronchiectasis in children from Qikiqtani (Baffin) Region, Nunavut, Canada

    01/01/2015

    Previous researchers have reported that Canadian Inuit children have markedly elevated rates of LRTI early in life. Our study suggests that this may lead to long-term pulmonary sequelae.

  12. Existence, Functional Impairment, and Lung Repair Potential of Endothelial Colony-Forming Cells in Oxygen-Induced Arrested Alveolar Growth

    01/05/2014

    We show for the first time that ECFCs exist in the distal vasculature of the developing mammalian lung, and their functional capacity is impaired in oxygen-induced lung damage. We also show that therapeutic supplementation with human umbilical cord blood–derived ECFCs is feasible, efficacious, and apparently safe in this experimental O2-induced model of BPD in neonatal mice.

  13. Long-term respiratory complications of congenital esophageal atresia with or without tracheoesophageal fistula: an update

    03/06/2013

    Recent studies suggest that in older patients, respiratory symptoms tend to be associated with atopy, but abnormal lung function tends to be associated with gastroesophageal reflux and with chest wall abnormalities.

  14. Airway Delivery of Mesenchymal Stem Cells Prevents Arrested Alveolar Growth in Neonatal Lung Injury in Rats

    01/12/2009

    MSC treatment preserved alveolar structure in a model of chronic lung disease in newborn rats caused by severe hyperoxia, which may be due to a paracrine effect on lung cells. MSCs may have therapeutic potential for preventing neonatal lung diseases characterized by alveolar damage.

Researchers

  1. Robert P Jankov

    Senior Scientist, CHEO Research Institute

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  2. Radha Jetty

    Investigator, CHEO Research Institute

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  3. Sherri Katz

    Senior Scientist, CHEO Research Institute

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  4. Tom Kovesi

    Investigator, CHEO Research Institute

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  5. Patricia Longmuir

    Senior Scientist, CHEO Research Institute

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  6. Dayre McNally

    Scientist, CHEO Research Institute

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  7. Katie O’Hearn

    Investigator, CHEO Research Institute

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  8. Amy Plint

    Senior Scientist, CHEO Research Institute

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  9. Dhenuka Radhakrishnan

    Investigator, CHEO Research Institute

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  10. Bernard Thébaud

    Senior Scientist, CHEO Research Institute

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