Dr. Yeganeh is a developmental cell biologist with research experience and expertise in Lung development, Neonatal lung diseases and Lung injury. He completed his PhD in Cancer Biology, Department of Biochemistry and Medical Genetics, University of Manitoba. He then started postdoctoral training under mentorship of Dr. Martin Post at the Hospital for Sick Children in Toronto where he pioneered a new field of investigation by exploring autophagy and apoptosis pathways in lung development and mechanisms of ventilation-induced lung injury. His current research interests include understanding the mechanisms of lung development and neonatal lung diseases, injury and repair. In addition, he has an active interest in uncovering the molecular mechanisms regulating autophagy and apoptosis to develop new methods and therapeutic strategies, including regenerative medicine and preventive treatments.
other areas of research:
Autophagy, Lung Development, Neonatal lung diseases, Stem cell
Thrombospondin-1 Plays a Major Pathogenic Role in Experimental and Human Bronchopulmonary Dysplasia
TSP-1 inhibits alveologenesis in neonatal rats, in part via the upregulated activity of TGF-β1. Observations in human lungs suggest a similar pathogenic role for TSP-1 in infants at risk for BPD.
Autophagy is required for lung development and morphogenesis
The current study aimed to investigate the occurrence of autophagy in the developing mouse lung and its regulatory role in airway branching and terminal sacculi formation. We found 2 windows of epithelial autophagy activation in the developing mouse lung, both resulting from AMPK activation.
Acid Sphingomyelinase Inhibition Attenuates Cell Death in Mechanically Ventilated Newborn Rat Lung
Ventilation-induced ceramides promote autophagy-mediated cell death, and identifies SMPD1 as a potential therapeutic target for the treatment of ventilation-induced lung injury in newborns.