Bronchiolitis is a viral illness that affects infants during winter months. It causes fever, cough, wheezing and difficulty breathing, and is a common cause for admission to hospital for children younger than one year of age. The team’s research suggests that two commonly used medications, epinephrine and dexamethasone, when given together, may reduce hospital admissions from bronchiolitis.
Research Projects
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Rates in Bronchiolitis Hospitalization, Intensive Care Unit Use, Mortality, and Costs From 2004 to 2018
01/01/2021
This represents a major increase in high-intensity hospital care and costs for one of the most common and cumulatively expensive conditions in pediatric hospital care.
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“Green Means Go”: Creation of a discharge checklist tool for patients with bronchiolitis
19/08/2020
Development of standardized medical discharge criteria for patients with bronchiolitis is a safe and effective way to improve predictability, transparency, communication and patient flow, while enhancing engagement of the health care team and patient and family satisfaction
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Chemical shift of 129Xe dissolved in red blood cells: Application to a rat model of bronchopulmonary dysplasia
01/12/2019
To measure the chemical shift of hyperpolarized 129Xe dissolved in the red blood cells(δRBC) of a cohort of rats exposed to hyperoxia and intermittent hypoxia (IH) to mimic human bronchopulmonary dysplasia, and to investigate the effect of xenon‐blood distribution time on δRBC.
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The Impact of Implementing a Preprinted Order Form for Inpatient Management of Otherwise Healthy Children Admitted to a Tertiary Care Centre With a Diagnosis of Bronchiolitis
01/12/2019
A retrospective chart review was performed of children admitted to the inpatient units at the Children's Hospital of Eastern Ontario (CHEO) with a discharge diagnosis of bronchiolitis.
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Are all stem cells equal? Systematic review, evidence map, and meta‐analyses of preclinical stem cell‐based therapies for bronchopulmonary dysplasia
01/11/2019
We performed a systematic review and network meta‐analysis (NMA) of preclinical studies testing cell‐based therapies in experimental neonatal lung injury.
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Oral aspiration, type 1 laryngeal cleft, and respiratory tract infections in canadian inuit children
01/06/2019
We conclude that swallowing dysfunction is not only prevalent amongst Canadian Inuit but clinically significant. This is the first study to demonstrate an association between swallowing dysfunction and respiratory morbidity in this population.
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Bronchiectasis in children from Qikiqtani (Baffin) Region, Nunavut, Canada
01/01/2015
Previous researchers have reported that Canadian Inuit children have markedly elevated rates of LRTI early in life. Our study suggests that this may lead to long-term pulmonary sequelae.
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Existence, Functional Impairment, and Lung Repair Potential of Endothelial Colony-Forming Cells in Oxygen-Induced Arrested Alveolar Growth
01/05/2014
We show for the first time that ECFCs exist in the distal vasculature of the developing mammalian lung, and their functional capacity is impaired in oxygen-induced lung damage. We also show that therapeutic supplementation with human umbilical cord blood–derived ECFCs is feasible, efficacious, and apparently safe in this experimental O2-induced model of BPD in neonatal mice.
Researchers
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Maala Bhatt
Scientist, CHEO Research Institute
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Melanie Buba
Investigator, CHEO Research Institute
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Robert P Jankov
Senior Scientist, CHEO Research Institute
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Radha Jetty
Investigator, CHEO Research Institute
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Tom Kovesi
Investigator, CHEO Research Institute
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Amy Plint
Senior Scientist, CHEO Research Institute
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Dhenuka Radhakrishnan
Scientist, CHEO Research Institute
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Bernard Thébaud
Senior Scientist, CHEO Research Institute
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Richard Webster
Investigator, CHEO Research Institute
