Bronchiolitis

Bronchiolitis is a viral illness that affects infants during winter months. It causes fever, cough, wheezing and difficulty breathing, and is a common cause for admission to hospital for children younger than one year of age. The team’s research suggests that two commonly used medications, epinephrine and dexamethasone, when given together, may reduce hospital admissions from bronchiolitis.

Research Projects

  1. The Impact of Implementing a Preprinted Order Form for Inpatient Management of Otherwise Healthy Children Admitted to a Tertiary Care Centre With a Diagnosis of Bronchiolitis

    01/12/2019

    A retrospective chart review was performed of children admitted to the inpatient units at the Children's Hospital of Eastern Ontario (CHEO) with a discharge diagnosis of bronchiolitis.

  2. Chemical shift of 129Xe dissolved in red blood cells: Application to a rat model of bronchopulmonary dysplasia

    01/12/2019

    To measure the chemical shift of hyperpolarized 129Xe dissolved in the red blood cells(δRBC) of a cohort of rats exposed to hyperoxia and intermittent hypoxia (IH) to mimic human bronchopulmonary dysplasia, and to investigate the effect of xenon‐blood distribution time on δRBC.

  3. Are all stem cells equal? Systematic review, evidence map, and meta‐analyses of preclinical stem cell‐based therapies for bronchopulmonary dysplasia

    01/11/2019

    We performed a systematic review and network meta‐analysis (NMA) of preclinical studies testing cell‐based therapies in experimental neonatal lung injury.

  4. Oral aspiration, type 1 laryngeal cleft, and respiratory tract infections in canadian inuit children

    01/06/2019

    We conclude that swallowing dysfunction is not only prevalent amongst Canadian Inuit but clinically significant. This is the first study to demonstrate an association between swallowing dysfunction and respiratory morbidity in this population.

  5. Bronchiectasis in children from Qikiqtani (Baffin) Region, Nunavut, Canada

    01/01/2015

    Previous researchers have reported that Canadian Inuit children have markedly elevated rates of LRTI early in life. Our study suggests that this may lead to long-term pulmonary sequelae.

  6. Existence, Functional Impairment, and Lung Repair Potential of Endothelial Colony-Forming Cells in Oxygen-Induced Arrested Alveolar Growth

    01/05/2014

    We show for the first time that ECFCs exist in the distal vasculature of the developing mammalian lung, and their functional capacity is impaired in oxygen-induced lung damage. We also show that therapeutic supplementation with human umbilical cord blood–derived ECFCs is feasible, efficacious, and apparently safe in this experimental O2-induced model of BPD in neonatal mice.

Researchers

  1. Maala Bhatt

    Investigator, CHEO Research Institute

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  2. Robert P Jankov

    Senior Scientist, CHEO Research Institute

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  3. Radha Jetty

    Investigator, CHEO Research Institute

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  4. Tom Kovesi

    Investigator, CHEO Research Institute

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  5. Amy Plint

    Senior Scientist, CHEO Research Institute

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  6. Catherine Pound

    Investigator, CHEO Research Institute

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  7. Dhenuka Radhakrishnan

    Investigator, CHEO Research Institute

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  8. Bernard Thébaud

    Senior Scientist, CHEO Research Institute

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