COVID-19 vaccination around the time of conception and risk of placenta-mediated adverse pregnancy outcomes

Although numerous studies have documented no association between COVID‐19 vaccination during pregnancy and maternal and fetal health outcomes, fewer studies have evaluated fetal health effects after COVID‐19 vaccination around the time of conception and early pregnancy, a time when maternal exposures may affect early placentation and the subsequent risk of placenta‐mediated adverse pregnancy outcomes.  This population‐based Canadian study provides additional evidence evaluating COVID‐19 vaccine administration around the start of pregnancy. While we identified no association with most placenta‐mediated outcomes, we report a slight increase in the rate of gestational hypertension. This could be a true association or attributed to residual confounding. Further research is needed to verify.