Ann Sprague

Investigator, CHEO Research Institute

Dr. Ann Sprague has long been involved in maternal-child care and research initiatives at the regional, national and international levels. Ann has worked in direct patient care, as a regional perinatal coordinator, as the founding Scientific Manager of BORN Ontario, as a researcher, and mentor to many students. She has obtained grants, led teams and fostered research and published in the clinical areas of dashboard use to improve care, birth centres, patient safety programs, H1N1 in pregnancy, hyperbilirubinemia, fetal fibronectin use, late preterm birth, fetal surveillance, bed rest in pregnancy, second stage of labour, and many others. She is currently a project advisor for BORN responsible for COVID-19 surveillance and research, investigating maternal and infant mortality, and mentoring research and analysis team members.

Research Projects

  1. Maternal-Newborn Health System Changes and Outcomes in Ontario Canada during Wave 1 of the COVID-19 Pandemic-A Retrospective Study


    Wave 1 of the COVID-19 pandemic led to system-level and clinical practice changes in Ontario maternal-newborn settings. Importantly, there is no evidence that these changes resulted in any contemporaneous increase in adverse perinatal outcomes, including stillbirth and preterm birth.

  2. Association of SARS-CoV-2 Infection During Pregnancy with Maternal and Perinatal Outcomes


    In this exploratory surveillance study conducted in Canada from March 2020 to October 2021, SARS-CoV-2 infection during pregnancy was significantly associated with increased risk of adverse maternal outcomes and preterm birth.

  3. Data Resource Profile: Better Outcomes Registry & Network (BORN) Ontario


    The Better Outcomes Registry & Network (BORN) Ontario collects pregnancy, birth and newborn information and outcomes data for nearly all births in Ontario, Canada. With nearly complete capture of the approximate 140 000 births each year in Ontario—∼40% of births in Canada—BORN Ontario is the largest perinatal registry in the country.