Caroline Zuijdwijk

Investigator, CHEO Research Institute

Caroline Zuijdwijk has been an active member of the Division of Endocrinology at CHEO since 2012. She received her medical degree from McMaster University, completed her pediatric residency at Memorial University and her pediatric endocrinology fellowship at CHEO. Following this, she pursued a research fellowship at the Hospital for Sick Children (Canadian Pediatric Endocrine Group Fellowship Award, 2011).  Dr. Zuijdwijk also holds a Postgraduate Diploma in Epidemiology (University of London) and a Certificate in Global Health (University of Toronto).

Dr. Zuijdwijk’s principal research interest is quality improvement in pediatric type 1 diabetes (T1D), both locally and abroad, with a special focus on the social determinants of health. Since 2011, she has lead (PI for two studies) and collaborated (IDREAM study) with an international multidisciplinary team for studies with the DREAM Trust, a charitable clinic for youth with T1D in India. Locally, she has been a co-investigator on a number of multi-centre RCTs, including the CGM TIME Trial (Timing of Initiation of Continuous Glucose Monitoring in Established Pediatric Type 1 Diabetes), CD-DIET (The Celiac Disease and Diabetes-Dietary Intervention and Evaluation Trial), and Medtronic’s Multi-center Trial in Adult and Pediatric Patients With Type 1 Diabetes Using Hybrid Closed Loop System and Control at Home. She has also supervised medical students and residents in pediatric T1D research.

In addition, Dr. Zuijdwijk was the CHEO site PI for the CIHR-funded multi-centre study Hypercalcemia, hypercalciuria, nephrolithiasis and CYP24A1 and has been a co-investigator on multiple studies lead by Dr. Leanne Ward in pediatric bone health.

Research Projects

  1. Social determinants of health linked with patient portal use in pediatric diabetes


  2. The impact of limited and strategic blood glucose monitoring on metabolic control in a type 1 diabetes clinic in Central India


    This study assessed whether the use of two SMBG tests per day improves glycemic control, measured by a change in HbA1c, in youth with T1D followed at the DREAM Trust (DT) in Nagpur, India.

  3. Where Have the Periods Gone? The Evaluation and Management of Functional Hypothalamic Amenorrhea


    Functional hypothalamic amenorrhea (FHA) is a common cause of amenorrhea in adolescent girls.

  4. Management of Type 1 diabetes in a limited resource context: A study of the diabetes research education and management trust model in Nagpur, Central India


    The DT charitable programme overcomes social status, gender inequalities and experience of social stigma to provide life-saving treatment to children with T1D in central India.

  5. Social Determinants of Health on Glycemic Control in Pediatric Type 1 Diabetes


    Measures of the SDH comprising Material and Social Deprivation were significantly associated with suboptimal glycemic control in our pediatric T1D cohort. Use of insulin pump therapy also predicted A1C and may have a moderating effect on these relationships.