Caroline Zuijdwijk

Investigator, CHEO Research Institute

Caroline Zuijdwijk has been an active member of the Division of Endocrinology at CHEO since 2012. She received her medical degree from McMaster University, completed her pediatric residency at Memorial University and her pediatric endocrinology fellowship at CHEO. Following this, she pursued a research fellowship at the Hospital for Sick Children (Canadian Pediatric Endocrine Group Fellowship Award, 2011).  Dr. Zuijdwijk also holds a Postgraduate Diploma in Epidemiology (University of London) and a Certificate in Global Health (University of Toronto).

Dr. Zuijdwijk’s principal research interest is quality improvement in pediatric type 1 diabetes (T1D), both locally and abroad, with a special focus on the social determinants of health. Since 2011, she has lead (PI for two studies) and collaborated (IDREAM study) with an international multidisciplinary team for studies with the DREAM Trust, a charitable clinic for youth with T1D in India. Locally, she has been a co-investigator on a number of multi-centre RCTs, including the CGM TIME Trial (Timing of Initiation of Continuous Glucose Monitoring in Established Pediatric Type 1 Diabetes), CD-DIET (The Celiac Disease and Diabetes-Dietary Intervention and Evaluation Trial), and Medtronic’s Multi-center Trial in Adult and Pediatric Patients With Type 1 Diabetes Using Hybrid Closed Loop System and Control at Home. She has also supervised medical students and residents in pediatric T1D research.

In addition, Dr. Zuijdwijk was the CHEO site PI for the CIHR-funded multi-centre study Hypercalcemia, hypercalciuria, nephrolithiasis and CYP24A1 and has been a co-investigator on multiple studies lead by Dr. Leanne Ward in pediatric bone health.

Research Projects

  1. A pediatric virtual care evaluation framework and its evolution using consensus methods


    The use of virtual care has increased dramatically in response to the COVID-19 pandemic, yet evidence is lacking regarding the impact of virtual care on patient outcomes, particularly in pediatrics. A standardized evaluation approach is required to support the integration of virtual care into pediatric health care delivery programs. The objective of this work was to develop a comprehensive and structured framework for pediatric virtual care evaluation. This framework is intended to engage and guide care providers, health centres, and stakeholders towards the development of a standardized approach to the evaluation of pediatric virtual care.

  2. Control-IQ Technology Positively Impacts Patient Reported Outcome Measures and Glycemic Control in Youth with Type 1 Diabetes in a Real-World Setting


    Initiation of Control-IQ technology in a real-world setting significantly reduced the impact of diabetes on daily life while simultaneously improving glycemic control

  3. Social determinants of health linked with patient portal use in pediatric diabetes


  4. The impact of limited and strategic blood glucose monitoring on metabolic control in a type 1 diabetes clinic in Central India


    This study assessed whether the use of two SMBG tests per day improves glycemic control, measured by a change in HbA1c, in youth with T1D followed at the DREAM Trust (DT) in Nagpur, India.

  5. Where Have the Periods Gone? The Evaluation and Management of Functional Hypothalamic Amenorrhea


    Functional hypothalamic amenorrhea (FHA) is a common cause of amenorrhea in adolescent girls.