David Mack

Senior Scientist, CHEO Research Institute

Dr. Mack is currently a Professor of Pediatrics at the University of Ottawa and Senior Scientist at the CHEO Research Institute. His Pediatric Gastroenterology Fellowship training was completed at the Hospital for Sick Children, University of Toronto. Following training, Dr. Mack was appointed to Faculty of Medicine at the University of Nebraska Medical Centre.

In 2001, he returned to Ottawa with a mandate and a vision to develop a Division of Pediatric Gastroenterology, Hepatology and Nutrition. Aligning excellence, staying focused on the goals, consistency, optimism, patience, integrity, respectfulness, passion and communication defined his tenure in leading the Division and developing IBD research endeavours. Dr. Mack is currently the Director of the CHEO IBD Centre, studying the importance and role of the intestinal microbiome in IBD.

He recently received the Canadian Association of Gastroenterology Distinguished Service Award and University of Ottawa Faculty of Medicine Distinguished Clinical Research Chair

Research Projects

  1. Mediterranean-Like Dietary Pattern Associations With Gut Microbiome Composition and Subclinical Gastrointestinal Inflammation

    01/09/2022

    No single food item was associated with microbial clusters or with the level of gut inflammation. However, we found that the consumption of a Mediterranean-like diet was strongly associated with decreased subclinical intestinal inflammation.

  2. Altered Gut Microbiome Composition and Function Are Associated With Gut Barrier Dysfunction in Healthy Relatives of Patients With Crohn’s Disease

    16/07/2022

    To our knowledge, this study is the first to assess human microbial associations with gut barrier function in vivo, and our large sample is a considerable strength of our study.

  3. Indirect and Out-of-Pocket Disease-associated Costs in Pediatric Inflammatory Bowel Disease: A Cross-sectional Analysis

    27/06/2022

    Indirect and OOP IBD-associated costs are substantial and more likely to affect families living in remote communities.

  4. Hospitalization With Clostridioides difficile in Pediatric Inflammatory Bowel Disease: a Population-Based Study

    07/06/2022

    Children with IBD have a markedly higher incidence of CDI identified during a hospitalization relative to children without IBD. Consequently, symptomatic children with IBD who are hospitalized should be screened for CDI.

  5. Targeted Assessment of Mucosal Immune Gene Expression Predicts Clinical Outcomes in Children with Ulcerative Colitis

    04/06/2022

    Targeted assessment of rectal mucosal immune gene expression predicts 52-week CSFR in treatment-naïve paediatric UC patients. Further exploration of IL-13Rɑ2 as a therapeutic target in UC and future studies of the epithelial-specific role of RORC in UC pathogenesis are warranted.