Wrist buckle fractures are among the most common injuries in children. Until recently, the North American practice preference was to immobilize these injuries with casts. CHEO researchers have found, however, that children treated with a removable splint had better physical functioning, had fewer difficulties with activities, returned to sports sooner, and suffered no greater pain than those treated with casts.

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Research Projects

  1. Standardized growth charts for children with osteogenesis imperfecta


    Our standardized OI type- and sex-specific growth charts can be used to assess the growth of individuals with OI from infancy to adulthood.

  2. Risk factors associated with prevalent vertebral fractures in Duchenne muscular dystrophy


    Readily measurable clinical variables were associated with prevalent VF in males with glucocorticoid-treated DMD. These variables may be useful to identify candidates for primary osteoporosis prevention after glucocorticoid initiation.

  3. Impact of a Prenatal Vitamin D Supplementation Program on Vitamin D Deficiency, Rickets and Early Childhood Caries in an Alaska Native Population


  4. Protocol for the systematic review of return‑to‑activity criteria in adolescent patients following an anterior cruciate ligament reconstruction


    Our objective is to systematically examine the literature and identify the criteria used when determining unrestricted RTA following an ACL reconstruction in an adolescent population.

  5. The Toddler’s Fracture


    Although a stable fracture with an excellent prognosis, opportunities exist to improve toddler's fractures diagnosis and treatment protocols, to optimize clinical management.

  6. Bone mineral Density Surveillance for Childhood, Adolescent, and Young Adult Cancer Survivors: Recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group.


    These recommendations facilitate evidence-based care for childhood, adolescent, and young adult cancer survivors internationally.

  7. Intravenous zoledronic acid versus placebo in children with glucocorticoid-induced osteoporosis: A randomized, double-blind, multi-national phase 3 trial


    LSBMDZ increased significantly on ZA compared with placebo over 1 year in children with GIO. Most AEs occurred after the first infusion.

  8. When Should Bisphosphonates Be Used in Children with Chronic Illness Osteoporosis?


    The decision to treat a child with a bisphosphonate hinges on distinguishing bone fragility from typical childhood fractures, and determining the potential for medication-unassisted recovery following an osteoporotic fragility fracture. While improvements in BMD are a well-known sign of recovery, restitution of bone structure is also a key indicator of recuperation, one that is unique to childhood, and that plays a pivotal role in the decision to intervene or not.

  9. Vitamin D supplementation for children with cancer: a systematic review and consensus recommendations


    Further research is needed; until then, we recommend dietary vitamin D/calcium intake in keeping with standard national guidelines, and periodic 25OHD monitoring to detect levels <20 ng/ml. Vitamin D/calcium supplementation is recommended in children with low levels, to maintain levels ≥20 ng/ml year-long.

  10. The Accuracy of Incident Vertebral Fracture Detection in Children Using Targeted Case-Finding Approaches


    These results provide guidance for targeting spine radiography in children at risk for IVF.

  11. Advances in Bone Assessment Methods in Children


    INTRODUCTION Pediatric bone diseases present with a variety of signs and symptoms. Although some diagnoses may be straightforward based on history and physical examination, other presentations require more extensive bone assessments. In addition, clinical followup, research studies, and drug trials are predicated on strong bone health assessment.

  12. Assessment of longitudinal bone growth in osteogenesis imperfecta using metacarpophalangeal pattern profiles


    COL1A1 and COL1A2 mutations affect bone growth not only by inducing fractures and bone deformities, but also through longitudinal growth deficits in bones that do not fracture or deform.

  13. Hands-On Workshops Improve Emergency Department Physicians’ Self-Reported Understanding of Pediatric Hand Injuries


    Knowledge sharing between specialists and generalists through combined didactic and hands-on workshops is an effective and well-received method of refining physician knowledge and increasing confidence in treating subspecialty-specific clinical presentations.

  14. The Accuracy of Prevalent Vertebral Fracture Detection in Children Using Targeted Case‐Finding Approaches


    Back pain was assessed by patient report, LS BMD was measured by dual‐energy X‐ray absorptiometry, and PVF were quantified on spine radiographs using the modified Genant semiquantitative method. Forty‐four patients (11.0%) had PVF.

  15. Osteogenesis Imperfecta: Skeletal Outcomes After Bisphosphonate Discontinuation at Final Height


    None of the patients sustained a new vertebral compression fracture during follow‐up.

  16. Bone Morbidity and Recovery in Children With Acute Lymphoblastic Leukemia: Results of a Six‐Year Prospective Cohort Study


    These results suggest the need for trials addressing interventions in the first 2 years of chemotherapy, targeting older children and children with more severe vertebral collapse, because these children are at greatest risk for incident VF and subsequent residual vertebral deformity.


  1. Maala Bhatt

    Scientist, CHEO Research Institute

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  2. Sasha Carsen

    Scientist, CHEO Research Institute

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  3. Kevin Cheung

    Investigator, CHEO Research Institute

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  4. Dina El Demellawy

    Investigator, CHEO Research Institute

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  5. James Jarvis

    Investigator, CHEO Research Institute

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  6. Marie-Eve Robinson

    Investigator, CHEO Research Institute

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  7. Jessica Romeo

    Investigator, CHEO Research Institute

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  8. Kevin Smit

    Investigator, CHEO Research Institute

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  9. Sandy Tse

    Investigator, CHEO Research Institute

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  10. Leanne Ward

    Senior Scientist, CHEO Research Institute

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