1
00:00:00,200 --> 00:00:04,000
Does lung volume exercises twice a day

2
00:00:03,900 --> 00:00:07,300
 help boys with Duchenne muscular dystrophy?

3
00:00:07,729 --> 00:00:09,843
(soft music)

4
00:00:11,700 --> 00:00:14,800
That's a great question, Duchenne muscular dystrophy 

5
00:00:14,800 --> 00:00:17,200
is a neuromuscular condition that is associated with

6
00:00:17,200 --> 00:00:19,900
weakening of the muscles including the breathing muscles.

7
00:00:20,300 --> 00:00:22,743
This can make it hard to take deep breaths

8
00:00:22,744 --> 00:00:25,143
and also increases risk of pneumonia.

9
00:00:25,343 --> 00:00:28,414
 Our study looked at lung volume recruitment exercises

10
00:00:28,415 --> 00:00:30,842
or breathing exercises that help somebody

11
00:00:30,843 --> 00:00:33,128
 to stack breaths one on top of another

12
00:00:33,129 --> 00:00:35,400
to get a really deep breath in.

13
00:00:35,400 --> 00:00:37,614
 We hope that this exercise use twice daily

14
00:00:37,615 --> 00:00:39,643
 over a two-year period would slow

15
00:00:39,644 --> 00:00:41,157
the decline in lung function.

16
00:00:41,158 --> 00:00:44,714
 We conducted the study at nine centers across Canada,

17
00:00:44,715 --> 00:00:46,485
with CHEO being the lead site

18
00:00:46,486 --> 00:00:48,670
and we looked at differences in

19
00:00:48,671 --> 00:00:50,856
lung function over two-year period.

20
00:00:50,857 --> 00:00:53,029
 Half of the boys in the study were assigned

21
00:00:53,030 --> 00:00:55,986
to use lung volume recruitment exercises twice a day,

22
00:00:55,987 --> 00:00:58,100
the other half used regular care.

23
00:00:58,101 --> 00:01:01,400
What we found was that over a two-year period

24
00:01:01,401 --> 00:01:04,257
 there was no real difference between those who use

25
00:01:04,258 --> 00:01:06,414
the lung volume recruitment exercises

26
00:01:06,415 --> 00:01:08,186
and those who didn't in terms of how quickly

27
00:01:08,187 --> 00:01:09,914
their lung function declined.

28
00:01:09,915 --> 00:01:12,729
What this means is that in individuals

29
00:01:12,730 --> 00:01:15,485
who have relatively preserved lung function 

30
00:01:15,486 --> 00:01:17,500
 and relatively normal lung function 

31
00:01:17,500 --> 00:01:19,900
the burden associated with doing this 

32
00:01:19,901 --> 00:01:23,386
therapy twice a day may not be as valuable for them.

33
00:01:23,387 --> 00:01:26,029
Certainly, we know in those with more advanced disease - 

34
00:01:26,030 --> 00:01:28,043
this is a very useful therapy, 

35
00:01:28,044 --> 00:01:30,314
but we probably don't need to start so early.