Yanfang Guo

Investigator, CHEO Research Institute

Dr. Yanfang Guo is a Clinical Investigator at CHEO RI, where she has been since 2016. In addition to her role as an Epidemiologist with BORN Ontario, Dr. Guo is a Senior Clinical Research Associate with Obstetrics and Maternal Newborn Investigations (OMNI) research group at Ottawa Hospital Research Institute, and Adjunct Professor with the School of Epidemiology and Public Health at the University of Ottawa.

Dr. Guo obtained her MSc (2006) and PhD (2011) in Epidemiology and Health Statistics at the School of Public Health of Central South University in China. Dr. Guo has extensive experience using large health administrative databases for pediatric and perinatal research. Her research interests include the design and implementation of complex perinatal epidemiological studies for gestational diabetes, obesity, gestational weight gain caesarean sections, and preeclampsia. Dr. Guo is an important source of methodological consultation and technical assistance on perinatal surveillance, research and evaluation at OMNI and BORN Ontario. As a new investigator, with leading/participating in data record linkage and data analysis in a number of complex research projects, she made important contributions in developing novel and creative studies for many multidisciplinary teams, by using BORN data with linkage to other databases at Institute for Clinical Evaluative Sciences (ICES) and Canadian Institute for Health Information (CIHI). She has been actively applying research funding from CIHR with collaborating external researchers and stakeholders. She has been very productive in research activities and currently obtained lots of achievements with leading 11 projects as principal investigator at CHEO RI using BORN data, submitted 10 grants as principal applicant/co-investigator since 2019 and published 7 papers at peer-reviewed journals since 2017.

Research Projects

  1. Racial differences in contribution of prepregnancy obesity and excessive gestational weight gain to large-for-gestational-age neonates


    Excessive gestational weight gain contributed more to LGA neonates than prepregnancy obesity in Whites and Asians, while there was no difference between excessive gestational weight gain and prepregnancy obesity in their contributions to the LGA neonates in Blacks. The differences are mostly driven by the differential prevalence of the two risk factors across racial groups.

  2. Racial/ethnic variations in gestational weight gain: a population-based study in Ontario


    Inadequate and excessive gestational weight gain (GWG) have both been linked with a number of adverse maternal and neonatal outcomes, which in turn also vary by race/ethnicity (Headen et al. 2012).